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LMN weakness may be con ned to the distribution of one spinal root (above) or one individual peripheral nerve (below). In such circumstances, the LMN signs are found only in the muscles supplied by the particular nerve root or peripheral nerve in question. Almost always there is sensory impairment in the area supplied by the nerve or nerve root. Examples of such lesions are an S1 nerve root syndrome caused by a prolapsed intervertebral disc, or a common peroneal nerve palsy caused by pressure in the region of the neck of the bula.

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When the boom ended home prices fell and mortgage payments could not be met by thousands upon thousands of homeowners, we experienced a rash of defaults and foreclosures The crashing housing market became a primary cause of the recession we presently are enduring Again, this was predictable Fifth, an adjunct to the subprime lending were the Federal National Mortgage Association, (Fannie Mae) and the Federal Home Mortgage Corporation (Freddie Mac) The government mission of these US government sponsored enterprises (GSE) created in 1968, was to keep mortgage interest rates low in order to increase their support for affordable housing Again a worthy goal In the past several years, these two GSEs were sometimes encouraged by the US Congress to continue to buy the subprime mortgagebacked securities.

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Gillon and Beauchamp s use of prima facie is inescapably authoritarian. Here is Gillon s version again:

It created a global market for subprime debt which gave rise to a false sense of security and resulted in the toxic assets that US government is now bailing out Sixth, the doctrine of Too Big to Fail, was in my opinion mishandled In theory of course, in a free market system, failure by any enterprise is an acceptable part of the bargain Government should never intervene to save a failing company Let the investor lose his investment when he has invested poorly or negligently Bankruptcy is the solution in normal circumstances A special methodology should be available for failure in unusual circumstances But as we know, what is acceptable policy in theory is not always acceptable in practice.

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More reliable identi cation is possible by using statistical tests However, these methods typically assume that the gene expression data follow a certain distribution, and require suf ciently large sample size that often cannot be achieved due to microarray experimental conditions or budget constraints Alternative techniques, such as bootstrapping, impose less rigorous requirements on the sample size and distribution while still providing reliable identi cation of differentially expressed genes Given the data, a statistical test explores whether a null hypothesis is valid and calculates the p-value, which refers to the probability that the observed statistics are generated by the null model If the p-value is smaller than some xed threshold (eg, 005), the null hypothesis is rejected.

FIGURE 1.5 Historic view of the persistent bandwidth bottleneck of Figure 1.1. Updates from Prof. L. Kleinrock.

When government concludes that there exists the danger of systemic risk, in other words when the entire economic system could unravel as a result of failure of one giant enterprise then government may feel beholden to intervene This has happened throughout world history A word of caution, however: When government concludes there is a need for intervention, it better be quite certain that a) there is in fact the danger of systemic failure, and b) the rules for intervention are clearly de ned In the case of Bear Stearns, the American government judged that the company was too big to fail However, a few months later, in the case of.

If the p-value is above the threshold, however, it should not be concluded that the original hypothesis is con rmed; the result of the test is that the observed events do not provide a reason to overturn it [25] The most common null hypothesis in microarray data analysis is that there is no difference between two groups of expression values for a given gene In this section, we brie y introduce the assumptions and requirements for several statistical tests that are often used for the identi cation of differentially expressed genes 4311 Parametric Statistical Approaches The Student s t-test examines the null hypothesis that the means of distributions from which two samples are obtained are equal The assumptions required for t-test are that the two distributions are normal and that their variances are equal.

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